Enhancing mRNA Drug Substance Stability: Advancing Thermostability Towards the Gold Standard of Room Temperature Storage
Time: 9:30 am
day: Day Two
Details:
- How can optimizing UTRs and stem loops stabilise mRNA secondary structure to enhance thermostability for increased scalability?
- How can modified nucleosides be used to improve stability for increased storage capacity?
- How can cap analogues and optimized poly(A) tails be incorporated to enhance mRNA integrity and prolong stability during storage?
- How have companies achieved mRNA drug storage at 2-8 degrees and how can this be leveraged for drug candidates?
