Roundtable Discussion – Addressing Formulation Challenges in Multivalent mRNA Vaccines: Ensuring Stability & Differentiation Across Strains

Time: 12:00 pm
day: Day Two

Details:

• How can formulation strategies ensure the compatibility and stability of multiple, highly similar mRNA sequences in a multivalent vaccine, minimising risks of degradation or loss of functionality?
• What role do advanced analytical techniques play in distinguishing and monitoring the stability of individual mRNA sequences with minimal differences, ensuring consistent quality across all components?
• How can excipient selection and LNP design be tailored to uniformly encapsulate and protect each mRNA molecule, reducing variability and improving efficacy?
• What preclinical and pre-formulation approaches can be applied to address stability challenges upfront, ensuring the success of multivalent vaccines during storage, transport, and administration?