dsRNA Control in mRNA Manufacturing From Reduction to Detection
Time: 11:30 am
day: Day One
Details:
- Double-stranded RNA (dsRNA) is a critical impurity in the IVT process, triggering innate immune responses that impact efficacy and safety.
- Minimizing dsRNA during manufacturing using a novel engineered T7 RNAP.
- Accurately quantifying dsRNA via ELISA-based methods to ensure product quality and regulatory compliance.
