Lise Besnard
Purification Scientist Sanofi
Seminars
Wednesday 20th May 2026
Optimising pDNA as a Starting Material to Enable Robust, GMP-Ready mRNA Manufacturing
9:00 am
- Defining pDNA as the gold-standard starting material for mRNA production to establish a stable, high-quality foundation for IVT efficiency across modalities
- Linking pDNA purity, analytics, and impurity profiles directly to IVT fidelity to reduce downstream variability and dsRNA burden upfront
- Designing and scaling E. coli–based pDNA fermentation and purification workflows to deliver consistent quality from development through GMP
