Manoj Pohare
Research, Department of Chemical, Material & Biological Engineering Associate University of Sheffield
Seminars
Wednesday 20th May 2026
Redesigning mRNA Drug Substance Manufacturing: Integrating IVT & Continuous Oligo-dT Purification to Reduce Cost & Improve Quality
10:30 am
- Designing an intergrated end-to-end RNA manufacturing system combining IVT synthesis, purification, formulation and sterile filtration
- Evaluating how integrated purification strategies support continuous and scalable manufacturing without compromising drug substance quality or regulatory robustness
- Lessons from the Innovate UK and CEPI-funded development programs, translating research-stage automation to GMP environments
Wednesday 20th May 2026
Developing a Continuous, Automated, and Digitalised End-to-End RNA Manufacturing Platform
11:30 am
- Designing an integrated end-to-end RNA manufacturing system combining IVT synthesis, purification, formulation, and sterile filtration
- Incorporating inline monitoring sensors for real-time feedback and process control across continuous RNA workflows
- Lessons from the Innovate UK and CEPI-funded development programs, translating research-stage automation to GMP environments
