Re-Engineering Lipid Nanoparticles for Emerging mRNA Payloads: Structural & Biological Design Considerations
- Examining how LNP internal structure and lipid composition govern stability, biodistribution, and immune interaction, and why these relationships become increasingly critical as payloads extend beyond conventional mRNA
- Adapting LNP architectures to accommodate new and mixed cargoes, including selfamplifying RNA and non-RNA payloads, while preserving functional performance in biologically relevant systems
- Investigating how small formulation choices influence biological behaviour, including immune response and in vivo performance, even when core components remain unchanged